The pathogenesis of hepatotoxicity of xylitol is currently unknown but it may be secondary to ATP depletion or reactive oxygen species. For currently unknown reasons, most dogs that develop liver failure do not show evidence of hypoglycemia on presentation.
Mild elevations of ALT few hundred are not uncommon and thought to possibly be due to mild hepatocyte swelling. It can take up to 3 days for liver values to increase.
It is currently recommend rechecking liver values, Tbili, phosphorus, platelets and clotting times daily for 3 days in dogs that may have ingested a possible hepatoxic dose. Hyperphosphotemia is associated with a worse prognosis in one study. Toxic doses of xylitol: 0. Trident gum contains 0.
Determining the amount of xylitol in the gum ingested can be very frustrating since owners rarely know how many pieces the dog actually ingested. Oral dental solutions should not be toxic at directed doses but can be dangerous if the concentrated bottle is ingested or a small dog drinks from a water bowl dosed for a large dog. Xylitol is absorbed very quickly within 20mins so there may not be a need for vomit induction here at DoveLewis we still do as long as dog is not clinical for hypoglycemia.
If nothing else this may help you determine how much gum was ingested if you can count the pieces in the vomit. The xylitol molecule is very small and does not bind well to activated charcoal so there is no need to give charcoal for absorptive purposes.
Are you a veterinary professional? Stay connected and sign up for our newsletter. Sign up for our newsletter. Share This. MedVet's Emergency Veterinarians November 30, What products contain xylitol?
The most common and easily accessible xylitol containing products include Ice Breakers, Orbit, Stride and Trident chewing gums. What problems does xylitol cause in dogs? Severe and sudden drops in blood sugar, liver failure, seizures, and death can all occur from xylitol ingestion in dogs. In humans xylitol does not cause release of insulin.
However in dogs, it is a potent stimulator of insulin release from the pancreas which leads to a rapid and severe drop in blood sugar levels. This low blood sugar level hypoglycemia can quickly become a life threatening situation. High doses of ingestion can also lead to liver failure for yet unknown reasons, often days after ingestion.
Pets that experience this condition do not always show signs of low blood sugar initially making follow up monitoring very important. How much xylitol does it take to cause problems?
0コメント